In London on Wednesday, the FTSE 100 gained 0.1 percent to 5,263.6, while the FTSE 250 was up 0.8 percent to 7,554.3 on a volume of 3.5 billion shares traded.

Shire Pharmaceuticals gained 1.7 percent to 655p on approval of its acquisition of Transkaryotic Therapies by shareholders of both companies.

Water company Kelda gained 2.1 percent to 710p as it was elevated to the FTSE 100 and upgraded to “buy” by Dresdner Kleinwort Wasserstein, which called Kelda’s efficiency and service the best in the sector. Dresdner also upgraded several other smaller water companies, which helped them see gains on the day as well. Northumbrian Water gained 2.6 percent to 220 ¼p, Pennon was up 1.1 percent to £10.57, and United Utilities added 0.7 percent to 638 ½p.

Reuters was up 1.5 percent to 387 ½p as ABN Amra upgraded the company to “buy” and advised investors to look at more than recent higher restructuring costs.

Tour operator MyTravel group lost 3 percent to 195p on a warning that it had already lost £2 million in cancellations and reparations due to disruptions caused by hurricanes and bombings.